Influenza A viruses: why focusing on M2e-based universal vaccines
Identifieur interne : 003514 ( Main/Exploration ); précédent : 003513; suivant : 003515Influenza A viruses: why focusing on M2e-based universal vaccines
Auteurs : Seyyed Mahmoud Ebrahimi [Iran] ; Majid Tebianian [Iran]Source :
- Virus Genes [ 0920-8569 ] ; 2011.
Abstract
Abstract: The threat of highly virulent avian influenza, such as H5N1 and swine-origin H1N1 influenza viruses, bring out an urgent need to develop a universal influenza vaccine, which may provide cross-protection against different strain of influenza A viruses. The extra-domain of influenza M2 protein (M2e), which is almost completely conserved among all subtypes of influenza A viruses, is considered as a promising candidate target for the development of a broad-spectrum recombinant influenza A vaccine. The results of several preclinical studies with M2e protein, with or without carriers, have already proved the successful protection of M2e-based vaccinated animal model against lethal challenge of heterologous and homologous influenza A viruses. Recently, the results of Phase I/II clinical trail studies with M2e-based vaccines have raised hopes for considering these vaccines against seasonal and pandemic influenza A strains. Hence, it is expected that more and more effective and safe universal influenza vaccines based on M2e will be developed for prevention of seasonal and pandemic influenza in the near future.
Url:
DOI: 10.1007/s11262-010-0547-7
Affiliations:
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Box 31975/148, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Virus Genes</title><title level="j" type="abbrev">Virus Genes</title><idno type="ISSN">0920-8569</idno><idno type="eISSN">1572-994X</idno><imprint><publisher ref="https://scientific-publisher.data.istex.fr/ark:/67375/H02-SWLMH5L1-1">Springer US</publisher><pubPlace>Boston</pubPlace><note type="URL">http://www.springer-ny.com</note><date type="published" when="2011">2011</date><biblScope unit="vol" from="42" to="42">42</biblScope><biblScope unit="issue" from="1" to="1">1</biblScope><biblScope unit="page" from="1">1</biblScope><biblScope unit="page" to="8">8</biblScope></imprint><idno type="ISSN">0920-8569</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0920-8569</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The threat of highly virulent avian influenza, such as H5N1 and swine-origin H1N1 influenza viruses, bring out an urgent need to develop a universal influenza vaccine, which may provide cross-protection against different strain of influenza A viruses. The extra-domain of influenza M2 protein (M2e), which is almost completely conserved among all subtypes of influenza A viruses, is considered as a promising candidate target for the development of a broad-spectrum recombinant influenza A vaccine. The results of several preclinical studies with M2e protein, with or without carriers, have already proved the successful protection of M2e-based vaccinated animal model against lethal challenge of heterologous and homologous influenza A viruses. Recently, the results of Phase I/II clinical trail studies with M2e-based vaccines have raised hopes for considering these vaccines against seasonal and pandemic influenza A strains. Hence, it is expected that more and more effective and safe universal influenza vaccines based on M2e will be developed for prevention of seasonal and pandemic influenza in the near future.</div></front></TEI><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Ebrahimi, Seyyed Mahmoud" sort="Ebrahimi, Seyyed Mahmoud" uniqKey="Ebrahimi S" first="Seyyed Mahmoud" last="Ebrahimi">Seyyed Mahmoud Ebrahimi</name></noRegion><name sortKey="Ebrahimi, Seyyed Mahmoud" sort="Ebrahimi, Seyyed Mahmoud" uniqKey="Ebrahimi S" first="Seyyed Mahmoud" last="Ebrahimi">Seyyed Mahmoud Ebrahimi</name><name sortKey="Ebrahimi, Seyyed Mahmoud" sort="Ebrahimi, Seyyed Mahmoud" uniqKey="Ebrahimi S" first="Seyyed Mahmoud" last="Ebrahimi">Seyyed Mahmoud Ebrahimi</name><name sortKey="Tebianian, Majid" sort="Tebianian, Majid" uniqKey="Tebianian M" first="Majid" last="Tebianian">Majid Tebianian</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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